January 1999, Volume 23, Issue 1, Pages 91 – 93

Case Report

Rapid autologous marrow recovery and eradication of infectious mononucleosis despite severe immunosuppression following second transplantation for aplastic anemia H-C Rossbach1,3, KM Hosler1, W Chamizo2, T Mueller2, NH Grana1, AG Lacson2 & JL Barbosa1 1Division of Pediatric Hematology/Oncology and Bone Marrow Transplantation, All Children’s Hospital, University of South Florida College of Medicine, St Petersburg, FL, USA     2Pathology, All Children’s Hospital, University of South Florida College of Medicine, St Petersburg, FL, USA     3Correspondence: Dr H-C Rossbach, 880 Sixth St So., St Petersburg, FL 33701, USA

Keywords

aplastic anemia;   second bone marrow transplant;   mixed chimerism;   autologous marrow recovery;   Epstein-Barr virus infection

Abstract

A patient with aplastic anemia failed to respond to immunosuppressive therapy and first marrow transplantation (BMT). Recovery of autologous hematopoiesis was rapid following a second stem cell transplant with a non-myeloablative preparatory regimen. The autologous immune response to infectious mononucleosis (IM) 4 weeks post-transplant was normal despite recent and ongoing severe immunosuppression.

Received 31 March 1998; Accepted 30 July 1998

^© Macmillan Publishers Ltd 1997