British Journal of Pharmacology

May 1998, Volume 124, Issue 1
Table of Contents

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Special Report

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate 1
José L. Boyer, Arvind Mohanram, Emidio Camaioni, Kenneth A. Jacobson & T. Kendall Harden
Abstract    Full Article (PDF)

Papers

Evidence that ATP acts at two sites to evoke contraction in the rat isolated tail artery 5
G.J. McLaren, K.S. Burke, K.J. Buchanan, P. Sneddon & C. Kennedy
Abstract    Full Article (PDF)

The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor 13
Karen A. McGurk, Marco Pistis, Delia Belelli, Anthony G. Hope & Jeremy J. Lambert
Abstract    Full Article (PDF)

Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture 21
Jin-Hua Tian, Wei Zhang, Yuan Fang, Wei Xu, David K. Grandy & Ji-Sheng Han
Abstract    Full Article (PDF)

The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs 27
A. Lecci, S. Giuliani, M. Tramontana, R. D Giorgio & C.A. Maggi
Abstract    Full Article (PDF)

Further insights into the anti-aggregating activity of NMDA in human platelets 35
Flavia Franconi, Mauro Miceli, Luisa Alberti, Giuseppe Seghieri, M. Graziella De Montis & Alessandro Tagliamonte
Abstract    Full Article (PDF)

The receptor subtype mediating the action of angiotensin II on intracellular sodium in rat proximal tubules 41
Patrick S.K. Wong & Edward J. Johns
Abstract    Full Article (PDF)

Modulation of spasmogen-stimulated Ins(1,4,5)P3 generation and functional responses by selective inhibitors of types 3 and 4 phosphodiesterase in airways smooth muscle 47
R.A. John Challiss, David Adams, Rajendra Mistry & C. David Nicholson
Abstract    Full Article (PDF)

Differential mechanism for the cell surface sorting and agonist-promoted internalization of the alpha1B-adrenoceptor 55
Akira Hirasawa, Takeo Awaji, Tatsuo Sugawara, Aiko Tsujimoto & Gozoh Tsujimoto
Abstract    Full Article (PDF)

Nitric oxide regulation of monkey myometrial contractility 63
Karri A. Kuenzli, Iain L.O. Buxton & Michael E. Bradley
Abstract    Full Article (PDF)

Carbachol stimulation of gastric acid secretion and its effects on the parietal cell 69
Arne K. Sandvik, Ronald Mårvik, Rod Dimaline & Helge L. Waldum
Abstract    Full Article (PDF)

Discovery of novel melanocortin4 receptor selective MSH analogues 75
Helgi B. Schiöth, Felikss Mutulis, Ruta Muceniece, Peteris Prusis & Jarl E.S. Wikberg
Abstract    Full Article (PDF)

Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist 83
C.S.J. Walpole, M.C.S. Brown, I.F. James, E.A. Campbell, P. McIntyre, R. Docherty, S. Ko, L. Hedley, S. Ewan, K.-H. Buchheit & L.A. Urban
Abstract    Full Article (PDF)

Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices 93
Anna Maria Pugliese, M. Beatrice Passani & Renato Corradetti
Abstract    Full Article (PDF)

Neuropeptide Y-induced potentiation of noradrenergic vasoconstriction in the human saphenous vein: involvement of endothelium generated thromboxane 101
Fulvia Fabi, Livio Argiolas, Giovanni Ruvolo & Paola del Basso
Abstract    Full Article (PDF)

Inhibition of nitrergic neurotransmission in the bovine retractor penis muscle by an oxidant stress: effects of superoxide dismutase mimetics 111
Josephine S.L. Mok, Karen Paisley & William Martin
Abstract    Full Article (PDF)

Effects of calcium and potassium supplements on arterial tone in vitro in spontaneously hypertensive rats 119
Jari-Petteri Tolvanen, Heikki Mäkynen, Xiumin Wu, Nina Hutri-Kähönen, Heikki Rsukoaho, Kirsi Karjala & Ilkka Pörsti
Abstract    Full Article (PDF)

Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors 129
John J. Kelly, Peter J. Barnes & Mark A. Giembycz
Abstract    Full Article (PDF)

Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione 141
M.P. Gordge, J.S. Hothersall & A.A. Noronha-Dutra
Abstract    Full Article (PDF)

Involvement of K+ channel permeability changes in the L-NAME and indomethacin resistant part of adenosine-5′-O-(2-thiodiphosphate)-induced relaxation of pancreatic vascular bed 149
D. Hillaire-Buys, J. Chapal, N. Linck, J.P. Blayac, P. Petit & M.M. Loubatières-Mariani
Abstract    Full Article (PDF)

P2Y1-receptors in human platelets which are pharmacologically distinct from P2YADP-receptors 157
M.S. Fagura, I.A. Dainty, G.D. McKay, I.P. Kirk, R.G. Humphries, M.J. Robertson, I.G. Dougall & P. Leff
Abstract    Full Article (PDF)

Irreversible binding of a carbostyril-based agonist and antagonist to the beta-adrenoceptor in DDT1 MF-2 cells and rat aorta 165
Malgorzata D. Deyrup, Phillip G. Greco, Deborah H. Otero, Donn M. Dennis, Craig H. Gelband &
Stephen P. Baker
Abstract    Full Article (PDF)

Pharmacological properties of P2X3-receptors present in neurones of the rat dorsal root ganglia 176
M.G. Rae, E.G. Rowan & C. Kennedy
Abstract    Full Article (PDF)

Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid 181
D.M. Eckman, N. Hopkins, C. McBride & K.D. Keef
Abstract    Full Article (PDF)

Ovalbumin-induced neurogenic inflammation in the bladder of sensitized rats 190
Amrita Ahluwalia, Sandro Giuliani, Ramona Scotland & Carlo Alberto Maggi
Abstract    Full Article (PDF)

Effect of chronic bradykinin B2 receptor blockade on blood pressure of conscious Dahl salt-resistant rats 197
Hiroya Mukai, Wayne R. Fitzgibbon, David W. Ploth & Harry S. Margolius
Abstract    Full Article (PDF)

Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo 206
Elizabeth M. Clifford, Sarah E. Gartside, Valerie Umbers, Philip J. Cowen, Mihály Hajós & Trevor Sharp
Abstract    Full Article (PDF)

Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor 213
Lei Xiao, Margaret A. Scofield & William B. Jeffries
Abstract    Full Article (PDF)

Responses to endothelium-dependent agonists in subcutaneous arteries excised from hypercholesterolaemic men 222
Tamara V. Lewis, Bridget A Cooper, Anthony M. Dart & Jaye P.F. Chin-Dusting
Abstract    Full Article (PDF)

Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4 229
Kate Blease, Anne Burke-Gaffney & Paul G. Hellewell
Abstract    Full Article (PDF)

Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function 238
David W. Laight, Amar V. Kaw, Martin J. Carrier & Erik E. Änggård
Abstract    Full Article (PDF)

Dual effects of dichloroacetate on cardiac ischaemic preconditioning in the rat isolated perfused heart 245
Michael D. Randall, Claudia A. Keon, Paul L. Greenhaff & Dumitru Constantin-Teodosiu
Abstract    Full Article (PDF)

Outward current produced by somatostatin (SRIF) in rat anterior cingulate pyramidal cells in vitro 252
G.A. Hicks, W. Feniuk & P.P.A. Humphrey
Abstract    Full Article (PDF)


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