January 1999, Volume 23, Issue 1, Pages 87 – 89

Case Report

Poor outcome of autologous stem cell transplantation for adult T cell leukemia/lymphoma: a case report and review of the literature K Tsukasaki1,3, T Maeda1, K Arimura1, J Taguchi1, T Fukushima1, Y Miyazaki1, Y Moriuchi1, K Kuriyama1, Y Yamada2 & M Tomonaga1 1Department of Hematology, Molecular Medicine Unit, Atomic Disease Institute, Nagasaki, Japan     2Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki, Japan     3Correspondence: Dr K Tsukasaki, Dept of Hematology, Atomic Disease Institute, Nagasaki University, Sakamoto 1-12-4, Nagasaki 852, Japan

Keywords

ATL;   HTLV-1;   auto-BMT;   auto-PBSCT

Abstract

A limited number of patients with adult T cell leukemia/lymphoma (ATL) who received autologous stem cell transplantation (ASCT) have been reported. We report here a case of fatal systemic Candida krusei infection in a female patient with ATL undergoing ASCT. All of the eight patients (including seven patients in the literature) with ATL who received ASCT developed relapse of ATL or death due to ASCT complication, irrespective of subtype or remission state of ATL, source or selection of SCT or conditioning regimen. At present, ASCT appears to provide little benefit for ATL in contrast to that for other types of aggressive non-Hodgkin’s lymphoma.

Received 13 July 1998; Accepted 18 August 1998

^© Macmillan Publishers Ltd 1997