January 1999, Volume 23, Issue 1, Pages 103 – 104

Case Report

Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukaemia RK Gregory1, RL Powles1, JG Treleaven1,5, ML Smith1, PS Mortimer2, A Wotherspoon3 & U Riley4 1Haemato-Oncology Unit, Royal Marsden Hospital, Sutton, Surrey, UK     2Department Dermatology, Royal Marsden Hospital, Sutton, Surrey, UK     3Department Histopathology, Royal Marsden Hospital, Sutton, Surrey, UK     4Department Microbiology, Royal Marsden Hospital, Sutton, Surrey, UK     5Correspondence: Dr JG Treleaven, Dept Haematology, The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK

Keywords

systemic candidiasis;   candida vasculitis;   Candida kruzei;   triazoles;   leukaemia;   bone marrow transplantation

Abstract

Candida kruzei-related systemic infections are increasing in frequency, particularly in patients receiving prophylaxis with antifungal triazoles. A Caucasian male with newly diagnosed acute myeloid leukaemia (AML M1) developed severe and persistent fever associated with a micropustular eruption scattered over the trunk and limbs during induction chemotherapy. Blood cultures grew Candida kruzei, and biopsies of the skin lesions revealed a candida vasculitis. He responded to high doses of liposomal amphotericin B and was discharged well from hospital.

Received 14 May 1998; Accepted 19 August 1998

^© Macmillan Publishers Ltd 1997