Leukemia

April 1997, Volume 11, Issue 4
Table of Contents

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Reviews

Mechanisms of apoptotic cell death 457
S Rowan & DE Fisher
Abstract    Full Article (PDF)

Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications 466
K Spiekermann, J Roesler, A Emmendoerffer, J Elsner & K Welte
Abstract    Full Article (PDF)

Original Manuscripts, Leading Article

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells 479
M Towatari, H Iida, M Tanimoto, H Iwata, M Hamaguchi & H Saito
Abstract    Full Article (PDF)

Therapy And Therapeutic Interventions

A randomized trial of high- vs standard-dose mitoxantrone with cytarabine in elderly patients with acute myeloid leukemia 485
EJ Feldman, K Seiter, L Damon, C Linker, H Rugo, C Ries, DC Case Jr, M Beer & T Ahmed
Abstract    Full Article (PDF)

Molecular Biology

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus 490
M Stanulla, J Wang, DS Chervinsky & PD Aplan
Abstract    Full Article (PDF)

Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells 497
M Yamaguchi, T Tanaka, M Waki, A Kitanaka, H Kamano, Y Kubota, H Ohnishi, J Takahara & S Irino
Abstract    Full Article (PDF)

Tumor Suppressor Genes, Signal Transduction And Cell

Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60) 504
AJ Freemerman, JA Vrana, RM Tombes, H Jiang, SP Chellappan, PB Fisher & S Grant
Abstract    Full Article (PDF)

Molecular Cytogenetics

Variant complex translocations involving chromosomes 1, 9, 9, 15 and 17 in acute promyelocytic leukemia without RARalpha/PML gene fusion rearrangement 514
SK Gogineni, HO Shah, M Chester, JH Lin, M Garrison, A Alidina, E Bayani & RS Verma
Abstract    Full Article (PDF)

Mosaicism of the 5q deletion as assessed by interphase FISH is a common phenomenon in MDS and restricted to myeloid cells 519
MJPL Kroef, MJW Bolk, P Muus, JW Wessels, GC Beverstock, R Willemze & JE Landegent
Abstract    Full Article (PDF)

Growth Factors And Cytokines

Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand 524
Y Ohmizono, H Sakabe, T Kimura, S Tanimukai, T Matsumura, H Miyazaki, SD Lyman & Y Sonoda
Abstract    Full Article (PDF)

Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl 531
W Piacibello, F Sanavio, MF Brizzi, L Garetto, A Severino, MG Aronica, G Dragonetti, M Aglietta & L Pegoraro
Abstract    Full Article (PDF)

Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines 541
HG Drexler, M Zaborski & H Quentmeier
Abstract    Full Article (PDF)

Induction of macrophagic differentiation and cytokine secretion by IgG1 molecules in human normal monocytes and myelogenous leukemia cells 552
A Micouin, D Rouillard & B Bauvois
Abstract    Full Article (PDF)

Sensitivity And Resistance To Leukemia

Differential effect of GM-CSF pretreatment on intracellular Ara-C metabolism in normal bone marrow mononuclear cells vs acute myeloid leukemia (AML) blasts 561
C Reuter, E Schleyer, C Rolf, B Wörmann, T Büchner & W Hiddemann
Abstract    Full Article (PDF)

Immunobiology

CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules 572
LE Van den Hove, SW Van Gool, P Vandenberghe, M Bakkus, K Thielemans, MA Boogaerts & JL Ceuppens
Abstract    Full Article (PDF)

Stem Cell Biology

Peripheral blood is a source of BCR-ABL-negative pre-progenitors in early chronic phase chronic myeloid leukemia 581
ID Lewis, DN Haylock, S Moore, LB To & TP Hughes
Abstract    Full Article (PDF)

Epidemiology

Socioeconomic factors in the families of children with lymphoid malignancy in the UAE 588
T Révész, C Mpofu, C Oyejide & A Bener
Abstract    Full Article (PDF)

Lymphoma

Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas 594
S Bajalica-Lagercrantz, F Piehl, J Lagercrantz, J Lindahl, G Weber, JP Kerckeart, A Porwit-MacDonald & M Nordenskjöld
Abstract    Full Article (PDF)

New Cell Line

Establishment of a novel human acute myeloblastic leukemia cell line (YNH-1) with t(16;21), t(1;16) and 12q13 translocations 599
K Yamamoto, H Hamaguchi, K Nagata, M Kobayashi, F Tanimoto & M Taniwaki
Abstract    Full Article (PDF)

Correspondence, Special Case Report

A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid 609
R-Q Yu, W Huang, S-J Chen, S-D Jiang & Z Chen
Abstract    Full Article (PDF)

Case Reports

Translocation (2;8)(p12;q24) in blastic transformation of atypical chronic myeloid leukemia 612
SK Ma, KL Au, TSK Wan & LC Chan
Full Article (PDF)

An extremely delayed cytogenetic response to interferon-alpha in a patient with chronic myeloid leukaemia 614
AJ Whiteway, CDL Reid & NCP Cross
Abstract    Full Article (PDF)

Letter to the Editor

Association between b3a2 BCR/ABL fusion and chronic myeloid leukemia with thrombocythemia onset: fortuitous or real? 617
YL Kwong
Full Article (PDF)


© Macmillan Publishers Ltd 1998