Gene Therapy

January 1998, Volume 5, Issue 1
Table of Contents

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News and Comments 1
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Editorial

Gene Therapy in the developing world 3
K Sikora
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Papers

Annual meeting of the American Association for Cancer Research 12-16 April 1997, San Diego, CA, USA 5
S Baatout
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Leptin gene therapy and daily protein administration: a comparative study in the ob/ob mouse 8
MA Morsy, MC Gu, JZ Zhao, DJ Holder, IT Rogers, WJ Pouch, SL Motzel, HJ Klein, SK Gupta, X Liang, MR Tota, CI Rosenblum & CT Caskey
Abstract    Full Article (PDF)

Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles 19
SS Floyd Jr, PR Clemens, MR Ontell, S Kochanek, CS Day, J Yang, SD Hauschka, L Balkir, J Morgan, MS Moreland, GW Feero, M Epperly & J Huard
Abstract    Full Article (PDF)

Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene 31
S Finke, B Trojaneck, P Lefterova, M Csipai, E Wagner, R Kircheis, A Neubauer, D Huhn, B Wittig & IGH Schmidt-Wolf
Abstract    Full Article (PDF)

Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia 40
PE Monahan, RJ Samulski, J Tazelaar, X Xiao, TC Nichols, DA Bellinger, MS Read & CE Walsh
Abstract    Full Article (PDF)

Gene transfer and expression in oligodendrocytes under the control of myelin basic protein transcriptional control region mediated by adeno-associated virus 50
H Chen, DM McCarty, AT Bruce, K Suzuki & K Suzuki
Abstract    Full Article (PDF)

Mini- and full-length dystrophin gene transfer induces the recovery of nitric oxide synthase at the sarcolemma of mdx4cv skeletal muscle fibers 59
A Decrouy, J-M Renaud, JA Lunde, G Dickson & BJ Jasmin
Abstract    Full Article (PDF)

Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector 65
A Cara, SM Rybak, DL Newton, R Crowley, SE Rottschafer, MS Reitz Jr & GL Gusella
Abstract    Full Article (PDF)

Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system 76
S A-Mohammadi & RE Hawkins
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Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer 85
G Cichon & M Strauss
Abstract    Full Article (PDF)

The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro 91
M Stern, NJ Caplen, JE Browning, U Griesenbach, F Sorgi, L Huang, DC Gruenert, C Marriot, RG Crystal, DM Geddes & EWFW Alton
Abstract    Full Article (PDF)

Transduction of human macrophages using a stable HIV-1/HIV-2-derived gene delivery system 99
P Corbeau, G Kraus & F Wong-Staal
Abstract    Full Article (PDF)

Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase 105
F Friedlos, S Court, M Ford, WA Denny & C Springer
Abstract    Full Article (PDF)

In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma 113
A Rosolen, E Frascella, C di Francesco, A Todesco, M Petrone, M Mehtali, F Zacchello, L Zanesco & M Scarpa
Abstract    Full Article (PDF)

Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins 121
S Andreansky, B He, J van Cott, J McGhee, JM Markert, GY Gillespie, B Roizman & RJ Whitley
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Brief Communications

ICAM-1 induction in respiratory cells exposed to a replication-deficient recombinant adenovirus in vitro and in vivo 131
E Nicolis, A Tamanini, P Melotti, R Rolfini, G Berton, MA Cassatella, A Bout, A Pavirani & G Cabrini
Abstract    Full Article (PDF)

Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum 137
K Crook, BJ Stevenson, M Dubouchet & DJ Porteous
Abstract    Full Article (PDF)


© Macmillan Publishers Ltd 1998