Gene Therapy

June 1998, Volume 5, Issue 6
Table of Contents

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News and Comments

GT News 723
Full Article (PDF)

Editorial

Adenoviral vectors: not to be sneezed at 725
PF Searle & V Mautner
Full Article (PDF)

Review

Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy 728
M Favrot, J-L Coll, N Louis & A Negoescu
Abstract    Full Article (PDF)

Papers

Poly (lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo 740
SJ Beer, CB Matthews, CS Stein, BD Ross, JM Hilfinger & BL Davidson
Abstract    Full Article (PDF)

Adenovirus-mediated wild-type p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo 747
T Riccioni, C Cirielli, X Wang, A Passaniti & MC Capogrossi
Abstract    Full Article (PDF)

A novel method for the direct quantification of gene transfer into cells using PCR in situ 755
C Catzavelos, C Ruedy, AK Stewart & I Dubé
Abstract    Full Article (PDF)

Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene 761
H Bai, R Morishita, I Kida, T Yamakawa, W Zhang, M Aoki, H Matsushita, A Noda, R Nagai, Y Kaneda, J Higaki, T Ogihara, Y Sawa & H Matsuda
Abstract    Full Article (PDF)

Recombinant adenoviral delivery for in vivo expression of scFv antibody fusion proteins 770
HA Whittington, LJ Ashworth & RE Hawkins
Abstract    Full Article (PDF)

IL-1/IL-3 gene therapy of non-small cell lung cancer (NSCLC) in rats using ‘cracked’ adenoproducer cells 778
MC Esandi, GD van Someren, A Bout, AH Mulder, DW van Bekkum, D Valerio & JL Noteboom
Abstract    Full Article (PDF)

Superiority of the ear pinna over muscle tissue as site for DNA vaccination 789
P Förg, P von Hoegen, W Dalemans & V Schirrmacher
Abstract    Full Article (PDF)

Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5) 798
KR Zinn, JT Douglas, CA Smyth, H-G Liu, Q Wu, VN Krasnykh, JD Mountz, DT Curiel & JM Mountz
Abstract    Full Article (PDF)

Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector 809
U Herrlinger, CM Kramm, KS Aboody-Guterman, JS Silver, K Ikeda, KM Johnston, PA Pechan, RF Barth, D Finkelstein, EA Chiocca, DN Louis & XO Breakefield
Abstract    Full Article (PDF)

In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector 820
MJ During, RJ Samulski, JD Elsworth, MG Kaplitt, P Leone, X Xiao, J Li, A Freese, JR Taylor, RH Roth, JR Sladek Jr, KL O’Malley & DE Redmond Jr
Abstract    Full Article (PDF)

Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells 828
M Pelegrin, M Marin, D Noël, M Del Rio, R Saller, J Stange, S Mitzner, WH Günzburg & M Piechaczyk
Abstract    Full Article (PDF)

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro 835
I Hickson, LJ Fairbairn, N Chinnasamy, LS Lashford, N Thatcher, GP Margison, TM Dexter & JA Rafferty
Abstract    Full Article (PDF)

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase 842
N Chinnasamy, JA Rafferty, I Hickson, LS Lashford, SJ Longhurst, N Thatcher, GP Margison, TM Dexter & LJ Fairbairn
Abstract    Full Article (PDF)

Targeting of a cholecystokinin-DNA complex to pancreatic cells in vitro and in vivo 848
DS Carpenter & RF Minchin
Abstract    Full Article (PDF)

Brief Communication

Influence of the DNA complexation medium on the transfection efficiency of lipospermine/DNA particles 855
A Kichler, W Zauner, M Ogris & E Wagner
Abstract    Full Article (PDF)


© Macmillan Publishers Ltd 1998