Leukemia

July 1997, Volume 11, Issue 7
Table of Contents

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Original Manuscripts, Clinical Studies

Clinical and biological characteristics of acute promyelocytic leukemia in Taiwan: a high relapse rate in patients with high initial and peak white blood cell counts during all-trans retinoic acid treatment 921
W-C Chou, J-L Tang, M Yao, Y-J Liang, F-Y Lee, M-T Lin, C-H Wang, M-C Shen, Y-C Chen & H-F Tien
Abstract    Full Article (PDF)

Therapy

A pilot study of all-trans retinoic acid in patients with Philadelphia chromosome-positive chronic myelogenous leukemia 929
J Cortes, H Kantarjian, S O’Brien, M Beran, E Estey, M Keating & M Talpaz
Abstract    Full Article (PDF)

Chronic Myeloid Leukemia

Expression of interferon regulatory factor (IRF) genes and response to interferon-alpha in chronic myeloid leukaemia 933
A Hochhaus, XH Yan, A Willer, R Hehlmann, MY Gordon, JM Goldman & JV Melo
Abstract    Full Article (PDF)

Sensitivity, Resistance To Therapy And Apoptosis

Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by Bcl-2 and Bcl-XL 940
A Benito, A Lerga, M Silva, J Leon & JL Fernandez-Luna
Abstract    Full Article (PDF)

Bcl-xL is heterogeneously expressed by acute myeloblastic leukaemia cells and is associated with autonomous growth in vitro and with P-glycoprotein expression 945
M Pallis, Y-M Zhu & NH Russell
Abstract    Full Article (PDF)

Sensitization of multidrug-resistant human leukemia cells with MDR1-targeted antisense and inhibition of drug-mediated MDR1 induction 950
X Li, AP Smyth, DJ Barrett, SP Ivy & E von Hofe
Abstract    Full Article (PDF)

Molecular Cytogenetics

Chromosomal breakpoints and changes in DNA copy number in refractory acute myeloid leukemia 958
W El-Rifai, E Elonen, M Larramendy, T Ruutu & S Knuutila
Abstract    Full Article (PDF)

Detection of 16 p deletions by FISH in patients with inv(16) or t(16;16) and acute myeloid leukemia (AML) 964
D Martinet, D Mühlematter, M Leeman, V Parlier, U Hess, J Gmür & M Jotterand
Abstract    Full Article (PDF)

Molecular Biology

DNA methylation patterns in the calcitonin gene region at first diagnosis and at relapse of acute lymphoblastic leukemia (ALL) 971
PAJ Leegwater, LHJ Lambooy, RA De Abreu, JPM Bökkerink & LP van den Heuvel
Abstract    Full Article (PDF)

Lack of ETV6 (TEL) gene rearrangements or p16INK4A/p15INK4B homozygous gene deletions in infant acute lymphoblastic leukemia 979
KW Maloney, JE Rubnitz, ML Cleary, LS Frankel, N Hakami, MP Link, DJ Pullen & SP Hunger
Abstract    Full Article (PDF)

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL) 984
Y Hatta, Y Yamada, M Tomonaga & HP Koeffler
Abstract    Full Article (PDF)

The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation 990
M Lübbert, R Henschler, M Kreutz, R Andreesen, R Mertelsmann & F Herrmann
Abstract    Full Article (PDF)

Growth Factors And Cytokines

Human A1, a Bcl-2-related gene, is induced in leukemic cells by cytokines as well as differentiating factors 998
JS Moreb & M Schweder
Abstract    Full Article (PDF)

Rarity of dominant-negative mutations of the G-CSF receptor in patients with blast crisis of chronic myeloid leukemia or de novo acute leukemia 1005
M Carapeti, A Soede-Bobok, A Hochhaus, H Sill, IP Touw, JM Goldman & NCP Cross
Abstract    Full Article (PDF)

Immunology

Sezary cell leukaemia: a distinct T cell disorder or a variant form of T prolymphocytic leukaemia? 1009
R Pawson, E Matutes, V Brito-Babapulle, H Maljaie, M Hedges, J Mercieca, M Dyer & D Catovsky
Abstract    Full Article (PDF)

Differentiation

Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid 1014
RL Redner, SJ Corey & EA Rush
Abstract    Full Article (PDF)

Interaction of vitamin D derivatives and granulocyte-macrophage colony-stimulating factor in leukaemic cell differentiation 1017
SY James, MA Williams, SM Kelsey, AC Newland & KW Colston
Abstract    Full Article (PDF)

Virology

Recurring proviral integration suggests a role for proto-oncogene activation in thymomas induced with Mo-MuLV-rescued BCR/ABL virus 1026
SS Clark
Abstract    Full Article (PDF)

New Cell Line

A new human cell line with pre-B cell phenotype and t(5;12) 1040
J Inglés-Esteve, A Aventín, C Azqueta, E Kádár, KM Bothner, B Amill, A Limón & J García López
Abstract    Full Article (PDF)

Brief Communication

Increased rejection of murine allogeneic bone marrow in presensitized recipients 1045
R van Os, T de Witte, JH Dillingh, PM Mauch & JD Down
Abstract    Full Article (PDF)

Biotechnical Methods Section Bts, Technical Reports

Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes 1049
W Terpstra, PJM Leenen, C van den Bos, A Prins, WAM Loenen, MMA Verstegen, S van Wyngaardt, N van Rooijen, AW Wognum, G Wagemaker, JJ Wielenga & B Löwenberg
Abstract    Full Article (PDF)

Automated high resolution PCR fragment analysis for identification of clonally rearranged immunoglobulin heavy chain genes 1055
B Linke, I Bolz, A Fayyazi, M von Hofen, Ch Pott, J Bertram, W Hiddemann & M Kneba
Abstract    Full Article (PDF)

Debate Round-Table

Editorial 1065
JP Marie
Full Article (PDF)

Multidrug resistance in acute leukemia: a comparison of different diagnostic methods 1067
G Pall, M Spitaler, J Hofmann, J Thaler & C Ludescher
Abstract    Full Article (PDF)

Immunocytochemical detection of the multidrug resistance-associated protein and P-glycoprotein in acute myeloid leukemia: impact of antibodies, sample source and disease status 1073
M Filipits, RW Suchomel, K Lechner & R Pirker
Abstract    Full Article (PDF)

Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia 1078
ML Den Boer, CM Zwaan, R Pieters, KM Kazemier, MMA Rottier, MJ Flens, RJ Scheper & AJP Veerman
Abstract    Full Article (PDF)

Multicentric evaluation of the MDR phenotype in leukemia 1086
J-P Marie, S Huet, A-M Faussat, J-Y Perrot, S Chevillard, V Barbu, C Bayle, J Boutonnat, F Calvo, L Campos-Guyotat, P Colosetti, J-L Cazin, P de Cremoux, C Delvincourt, C Demur, B Drenou, O Fenneteau, J Feuillard, A Garnier-Suillerot, P Genne, M-C Gorisse, P Gosselin, H Jouault, R Lacave, G Le Calvez, M-C Léglise, S Léonce, M Manfait, M Maynadié, H Merle-Béral, J-L Merlin, M Mousseau, H Morjani, F Picard, F Pinguet, P Poncelet, E Racadot, M Raphael, B Richard, J-F Rossi, N Schlegel, P Vielh, D-C Zhou & J Robert
Abstract    Full Article (PDF)

French multicentric evaluation of mdr1 gene expression by RT-PCR in leukemia and solid tumours. Standardization of RT-PCR and preliminary comparisons between RT-PCR and immunohistochemistry in solid tumours 1095
S Chevillard, Ph Vielh, P Validire, JP Marie, AM Faussat, V Barbu, C Bayle, J Bénard, C Bonnal, J Boutonnat, F Calvo, J Charrier, A Clary, P Colosetti, L Danel-Moore, P Decrémoux, C Delvincourt, F Finat-Duclos, Ph Genne, A Kataki, JC Kouyoumdjian, R Lacave, C Maugard, JL Merlin, M Mousseau, F Pinguet, V Quillien, M Raphael, B Richard, P Verrelle & J Robert
Abstract    Full Article (PDF)

Methods to detect P-glycoprotein and implications for other drug resistance-associated proteins 1107
WT Beck & TM Grogan
Abstract    Full Article (PDF)

Theoretical and practical considerations for the measurement of P-glycoprotein function in acute myeloid leukemia 1110
HJ Broxterman, J Lankelma, HM Pinedo, CA Eekman, DCR Währer, GJ Ossenkoppele & GJ Schuurhuis
Abstract    Full Article (PDF)

Monoclonal antibodies specific for P-glycoprotein 1119
E Okochi, T Iwahashi & T Tsuruo
Abstract    Full Article (PDF)

Flow cytometric analysis of P-glycoprotein function using rhodamine 123 1124
J Pétriz & J García-López
Abstract    Full Article (PDF)

Characterization of functional assays of multidrug resistance P-glycoprotein transport activity 1131
I Bosch, CL Crankshaw, D Piwnica-Worms & JM Croop
Abstract    Full Article (PDF)

Flow cytometric analysis of the multiple drug resistance phenotype 1138
A Krishan, A Sauerteig, I Andritsch & L Wellham
Abstract    Full Article (PDF)

Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe 1147
JM Kühnel, JY Perrot, AM Faussat, JP Marie & MA Schwaller
Abstract    Full Article (PDF)

Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells 1156
TJ Lampidis, Y-F Shi, CL Calderon, D Kolonias, H Tapiero & N Savaraj
Abstract    Full Article (PDF)

Assays for the analysis of P-glycoprotein in acute myeloid leukemia and CD34 subsets of AML blasts 1160
P Sonneveld & E Wiemer
Abstract    Full Article (PDF)

Detection of multidrug resistance gene expression in multiple myeloma 1166
WS Dalton
Abstract    Full Article (PDF)

Anthracycline subcellular distribution in human leukemic cells by microspectrofluorometry: factors contributing to drug-induced cell death and reversal of multidrug resistance 1170
H Morjani, J-M Millot, R Belhoussine, S Sebille & M Manfait
Abstract    Full Article (PDF)

Apoptosis and resistance to daunorubicin in human leukemic cells 1180
T Efferth, U Fabry & R Osieka
Abstract    Full Article (PDF)


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