Gene Therapy

April 1998, Volume 5, Issue 4
Table of Contents

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News and Comments

427
Full Article (PDF)

Editorial

Impact of a new generation of gene transfer markers on gene therapy 429
B Fehse, Z Li, UM Schade, A Uhde & AR Zander
Full Article (PDF)

Papers

Effects of macrophage depletion and anti-CD40 ligand on transgene expression and redosing with recombinant adenovirus 431
CS Stein, JL Pemberton, N van Rooijen & BL Davidson
Abstract    Full Article (PDF)

Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector – potential glioblastoma targeting 440
EA McKie, DI Graham & SM Brown
Abstract    Full Article (PDF)

Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration 451
MM van der Eb, SJ Cramer, Y Vergouwe, FHE Schagen, JHJM van Krieken, AJ van der Eb, IHM Borel Rinkes, CJH van de Velde & RC Hoeben
Abstract    Full Article (PDF)

Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome 459
T Hirano, J Fujimoto, T Ueki, H Yamamoto, T Iwasaki, R Morisita, Y Sawa, Y Kaneda, H Takahashi & E Okamoto
Abstract    Full Article (PDF)

Adenovirus vectors for gene transduction into mobilized blood CD34+ cells 465
M Bregni, S Shammah, F Malaffo, M Di Nicola, M Milanesi, M Magni, P Matteucci, F Ravagnani, CT Jordan, S Siena & AM Gianni
Abstract    Full Article (PDF)

Complete correction of acid alpha-glucosidase deficiency in Pompe disease fibroblasts in vitro, and lysosomally targeted expression in neonatal rat cardiac and skeletal muscle 473
DF Pauly, DC Johns, LA Matelis, JH Lawrence, BJ Byrne & PD Kessler
Abstract    Full Article (PDF)

Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study 481
Y Sun, K Jurgovsky, P Möller, S Alijagic, T Dorbic, J Georgieva, B Wittig & D Schadendorf
Abstract    Full Article (PDF)

Drug inducible transgene expression in brain using a herpes simplex virus vector 491
T Oligino, PL Poliani, Y Wang, SY Tsai, BW O’Malley, DJ Fink & JC Glorioso
Abstract    Full Article (PDF)

Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression 497
MA Abina, M Tulliez, C Lacout, N Debili, J-L Villeval, F Pflumio, F Wendling, W Vainchenker & H Haddada
Abstract    Full Article (PDF)

Regional ‘pro-drug’ gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma 507
N Topf, S Worgall, NR Hackett & RG Crystal
Abstract    Full Article (PDF)

Myosin regulatory elements as vectors for gene transfer by intramuscular injection 514
M Skarli, A Kiri, G Vrbova, CA Lee & G Goldspink
Abstract    Full Article (PDF)

A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor 521
J Fominaya, C Uherek & W Wels
Abstract    Full Article (PDF)

Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system 531
C Hofmann & M Strauss
Abstract    Full Article (PDF)

Systemic action of human growth hormone following adenovirus-mediated gene transfer to rat submandibular glands 537
X He, CM Goldsmith, Y Marmary, RB Wellner, AF Parlow, LK Nieman & BJ Baum
Abstract    Full Article (PDF)

Lipofection of cultured mouse muscle cells: a direct comparison of Lipofectamine and DOSPER 542
E Dodds, MG Dunckley, K Naujoks, U Michaelis & G Dickson
Abstract    Full Article (PDF)

Brief Communications

Retroviral gene transfer to the liver in vivo during tri-iodothyronine induced hyperplasia 552
SJ Forbes, M Themis, MR Alison, C Selden, C Coutelle & HJF Hodgson
Abstract    Full Article (PDF)

Rapid analysis and efficient selection of human transduced primitive hematopoietic cells using the humanized S65T green fluorescent protein 556
F Mazurier, F Moreau-Gaudry, V Maguer-Satta, S Salesse, V Pigeonnier-Lagarde, C Ged, F Belloc, F Lacombe, FX Mahon, J Reiffers & H de Verneuil
Abstract    Full Article (PDF)

FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors 563
AT Larregina, AE Morelli, RA Dewey, MG Castro, A Fontana & PR Lowenstein
Abstract    Full Article (PDF)

Corrigenda

Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers 569
SL Chadwick, HD Kingston, M Stern, RM Cook, BJ O’Connor, M Lukasson, RP Balfour, M Rosenberg, SH Cheng, AE Smith, DP Meeker, DM Geddes & EWFW Alton
Full Article (PDF)

Intracellular inhibition of HIV-1 replication using a dual protein- and RNA-based strategy 570
L-X Duan, M Zhu, I Ozaki, DL Wei & RJ Pomerantz
Full Article (PDF)


© Macmillan Publishers Ltd 1998