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Leukemia
Normal and Malignant Hemopoiesis

January 2001, Volume 15, Issue 1
Table of Contents

Journal Home
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Spotlight on Apoptosis

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies 1
AM Senderowicz
Abstract    Full Article (PDF)

Editorial

Hypothesis: Phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia 10
TA McDonald, NT Holland, C Skibola, P Duramad & MT Smith
Abstract    Full Article (PDF)

Reviews

Molecular signals in anti-apoptotic survival pathways 21
DM O’Gorman & TG Cotter
Abstract    Full Article (PDF)

Chronic neutrophilic leukemia (CNL): a clinical, pathologic and cytogenetic study 35
MA Elliott, GW Dewald, A Tefferi & CA Hanson
Abstract    Full Article (PDF)

Original Manuscripts

Therapy and Competing Risks in Childhood AML
Second malignancy after treatment of childhood acute myeloid leukemia 41
W Leung, RC Ribeiro, M Hudson, X Tong, DK Srivastava, JE Rubnitz, JT Sandlund, BI Razzouk, WE Evans & C-H Pui
Abstract    Full Article (PDF)

Prognosis in Childhood AML
Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia 46
MM Bisschop, T Révész, M Bierings, JF van Weerden, ER van Wering, K Hählen & A van der Does-van den Berg
Abstract    Full Article (PDF)

Autologous Grafting in Childhood ALL and Long-term Results
Purified autologous grafting in childhood acute lymphoblastic leukemia in second remission: evidence for long-term clinical and molecular remissions 50
A Balduzzi, G Gaipa, S Bonanomi, M Dassi, P Perseghin, F Buscemi, E D’Aniello, A Rovelli, R Schirò, D Longoni, A Rambaldi, C Uderzo & A Biondi
Abstract    Full Article (PDF)

Technical Clinical Correlates in Patients with AML1
Comparison of outcome in acute myelogenous leukemia patients with translocation (8;21) found by standard cytogenetic analysis and patients with AML1/ETO fusion transcript found only by PCR testing 57
JE Sarriera, M Albitar, Z Estrov, C Gidel, R Aboul-Nasr, T Manshouri, S Kornblau, K-S Chang, H Kantarjian & E Estey
Abstract    Full Article (PDF)

Progenitors’ Cell Cycle Status in CML
Proliferating status of peripheral blood progenitor cells from patients with BCR/ABL-positive chronic myelogenous leukemia 62
A Krämer, H Löffler, J Bergmann, A Hochhaus & R Hehlmann
Abstract    Full Article (PDF)

Pharmacodynamics and Pharmacogenomics
Modulation of ara-CTP levels by fludarabine and hydroxyurea in leukemic cells 69
M Ahlmann, C Lanvers, K Lümkemann, C Rössig, A Freund, M Baumann & J Boos
Abstract    Full Article (PDF)

6-Mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia 74
K Schmiegelow & U Bretton-Meyer
Abstract    Full Article (PDF)

Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance 80
M Smeets, R Raymakers, P Muus, G Vierwinden, P Linssen, R Masereeuw & T de Witte
Abstract    Full Article (PDF)

Molecular Cytogenetics
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation 89
I Kitabayashi, Y Aikawa, A Yokoyama, F Hosoda, M Nagai, N Kakazu, T Abe & M Ohki
Abstract    Full Article (PDF)

Detection of E2A translocations in leukemias via fluorescence in situ hybridization 95
T Boomer, M Varella-Garcia, L McGavran, L Meltesen, AS Olsen & SP Hunger
Abstract    Full Article (PDF)

Apoptosis and C/EPB in Mice Myeloid Cells
C/EBP -/- mice: increased rate of myeloid proliferation and apoptosis 103
W Verbeek, M Wächter, J Lekstrom-Himes & HP Koeffler
Abstract    Full Article (PDF)

Ship in AML and Normal
The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro 112
S Horn, J Meyer, J Heukeshoven, B Fehse, C Schulze, S Li, J Frey, S Poll, C Stocking & M Jücker
Abstract    Full Article (PDF)

Immunology
Immunoglobulin lambda isotype gene rearrangements in B cell malignancies 121
T Tümkaya, M van der Burg, R Garcia Sanz, M Gonzalez Diaz, AW Langerak, JF San Miguel & JJM van Dongen
Abstract    Full Article (PDF)

HLA class I antigen cell surface expression is preserved on acute myeloid leukemia blasts at diagnosis and at relapse 128
M Wetzler, MR Baer, SJ Stewart, K Donohue, L Ford, CC Stewart, EA Repasky & S Ferrone
Abstract    Full Article (PDF)

Minimal Residual Disease in B-ALL and Clonal Analysis
Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy 134
V de Haas, OJHM Verhagen, AEGKr von dem Borne, W Kroes, H van den Berg & CE van der Schoot
Abstract    Full Article (PDF)

Cell Line Models for T Leukemia
Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice 141
DS Chervinsky, DH Lam, X-F Zhao, MP Melman & PD Aplan
Abstract    Full Article (PDF)

Lymphoma
Establishment of a follicular lymphoma cell line (FLK-1) dependent on follicular dendritic cell-like cell line HK 148
Y Kagami, J Jung, YS Choi, K Osumi, S Nakamura, Y Morishima & M Seto
Abstract    Full Article (PDF)

Myeloma and Plasma Cell Disease
Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia 157
T Uchida, T Kinoshita, T Ohno, H Ohashi, H Nagai & H Saito
Abstract    Full Article (PDF)

Bio-technical Methods Section (BTS)

Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay 166
X Chen, Q Pan, P Stow, FG Behm, R Goorha, C-H Pui & GAM Neale
Abstract    Full Article (PDF)

Angiogenesis in multiple myeloma: correlation between in vitro endothelial colonies growth (CFU-En) and clinical-biological features 171
M Dominici, D Campioni, F Lanza, M Luppi, P Barozzi, S Pauli, R Milani, F Cavazzini, M Punturieri, R Trovato, G Torelli & G Castoldi
Abstract    Full Article (PDF)

Detection of secondary genetic aberrations in follicle center cell derived lymphomas: assessment of the reliability of comparative genomic hybridization and standard chromosome analysis 177
A Viardot, JI Martin-Subero, R Siebert, S Harder, S Gesk, M Bentz & B Schlegelberger
Abstract    Full Article (PDF)

Correspondence

The natural history and clinico-pathological features of the variant form of hairy cell leukemia 184
E Matutes, A Wotherspoon, V Brito-Babapulle & D Catovsky
Full Article (PDF)

Severe thrombocytopenia and clinical bleeding associated with rituximab infusion in a lymphoma patient with massive splenomegaly without leukemic invasion 186
C Rigamonti, C Volta, S Colombi, L Forti, F Savinelli, G Gaidano & E Bartoli
Full Article (PDF)

Remission of severe cold agglutinin disease Rituximab therapy 187
N Layios, E Van Den Neste, E Jost, V Deneys, JM Scheiff & A Ferrant
Full Article (PDF)

Age cohort subgroups in adult acute myeloid leukaemia studies – the population perspective 188
SJ Proctor & PRA Taylor
Full Article (PDF)

CD13/aminopeptidase N involvement in dendritic cell maturation 190
VHJ van der Velden, PJM Leenen & HA Drexhage
Full Article (PDF)

Deletion of the multidrug resistance protein 1 (MRP1) gene in acute myeloid leukemia patients with inversion 16: expression of MRP1homologues 191
DM van der Kolk, EGE de Vries & E Vellenga
Full Article (PDF)

Is HLA-DR4 or the HLA-DRB1*0402 allele associated with decreased risk for CML? 192
G Pawelec & W Wagner
Full Article (PDF)

© Macmillan Publishers Ltd 2001

Nature Publishing Group Specialist Journals have a substantial list of leading international journals in the key areas of science and medicine. Specialist fields covered include: bone marrow transplantation, cell death and differentiation, critical care/intensive care, dentistry, dentomaxillofacial radiology, environmental epidemiology, gene therapy, hematology, human and experimental toxicology, exposure analysis, human hypertension, impotence research, industrial microbiology, industrial health, information systems, leukemia, lupus, microcirculation, molecular psychiatry, multiple sclerosis, neuroscience, nursing, nutrition, obesity, occupational medicine, oncology, oncology pharmacy practice, operations research, optometry and ophthalmology, oral diseases, orthopedics, paraplegia, perinatology, pharmacology, psychiatry, public health, spinal injury and disease.