British Journal of Pharmacology

August 1998, Volume 124, Issue 7
Table of Contents

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Special Reports

Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle 1335
O.N. Osipenko, D. Alexander, M.R. MacLean & A.M. Gurney
Abstract    Full Article (PDF)

Flunitrazepam rapidly reduces GABAA receptor subunit protein expression via a protein kinase C-dependent mechanism 1338
Jonathan D. Johnston, Sally A. Price & David R. Bristow
Abstract    Full Article (PDF)

Action potential shortening through the putative beta4-adrenoceptor in ferret ventricle: comparison with beta1– and beta2-adrenoceptor-mediated effects 1341
Martin D. Lowe, Andrew A. Grace, Jamie I. Vandenberg & Alberto J. Kaumann
Abstract    Full Article (PDF)

Original Articles

5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression 1345
R. Verheggen, A.G. Hundeshagen, A.M. Brown, M. Schindler & A.J. Kaumann
Abstract    Full Article (PDF)

Theophylline dilates rat diaphragm arterioles via the prostaglandins pathway 1355
Gawiyou Danialou, Eric Vicaut, Michel Aubier & Jorge Boczkowski
Abstract    Full Article (PDF)

Excitatory transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of cannabinoid CB1 receptors 1363
Angelo A. Izzo, Nicola Mascolo, Francesca Borrelli & Francesco Capasso
Abstract    Full Article (PDF)

The intravenous administration of tumor necrosis factor alpha, interleukin 8 and macrophage-derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric oxide production 1369
B.M. Tavares-Murta, F.Q. Cunha & S.H. Ferreira
Abstract    Full Article (PDF)

Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum 1375
P.J. Johnson, J.C. Bornstein & E. Burcher
Abstract    Full Article (PDF)

Increase in tumor necrosis factor-alpha production linked to the toxicity of indomethacin for the rat small intestine 1385
Viviane Bertrand, Rosine Guimbaud, Micheline Tulliez, Cédric Mauprivez, Philippe Sogni, Daniel Couturier, Jean-Paul Giroud, Stanislas Chaussade & Laurence Chauvelot-Moachon
Abstract    Full Article (PDF)

Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats – role of capsaicin-sensitive sensory neurons 1395
Kimihito Tashima, Roman Korolkiewicz, Masafumi Kubomi & Koji Takeuchi
Abstract    Full Article (PDF)

Receptors involved in nerve-mediated vasoconstriction in small arteries of the rat hepatic mesentery 1403
Jacqueline K. Phillips, Allan J. McLean & Caryl E. Hill
Abstract    Full Article (PDF)

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography 1413
N.H. Hendrikse, A.H. Schinkel, E.G.E De Vries, E. Fluks, W.T.A. Van der Graaf, A.T.M. Willemsen, W. Vaalburg & E.J.F. Franssen
Abstract    Full Article (PDF)

Modulation of Delta9-tetrahydrocannabinol-induced hypothermia by fluoxetine in the rat 1419
Daniel T. Malone & David A. Taylor
Abstract    Full Article (PDF)

Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells 1425
Aya Nakata, Osamu Kaminuma, Akio Mori, Koji Ogawa, Hideo Kikkawa, Kazuaki Naito, Katsuo Ikezawa, Matsunobu Suko & Hirokazu Okudaira
Abstract    Full Article (PDF)

Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol) 1433
Masami Fukuoka, Yasuhiro Ogino, Hiroaki Sato, Tomohiro Ohta & Keiji Komoriya
Abstract    Full Article (PDF)

Influence of a selective guanylate cyclase inhibitor, and of the contraction level, on nitrergic relaxations in the gastric fundus 1439
R.A. Lefebvre
Abstract    Full Article (PDF)

Comparison of contractions produced by carbachol, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle 1449
M. Takemoto, K. Takagi, K. Ogino & T. Tomita
Abstract    Full Article (PDF)

Effect of atrial natriuretic peptide and cyclic GMP phosphodiesterase inhibition on collagen synthesis by adult cardiac fibroblasts 1455
Juliana Redondo, Jill E. Bishop & Martin R. Wilkins
Abstract    Full Article (PDF)

2′,3′-O-(2,4,6- trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP) – a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels 1463
C.J. Lewis, A. Surprenant & R.J. Evans
Abstract    Full Article (PDF)

Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetized rat 1467
J.S. Clayton, K.L. Clark, E.J. Johns & G.M. Drew
Abstract    Full Article (PDF)

Hepatic structure-pharmacokinetic relationships: The hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid 1475
Daniel Y. Hung, George D. Mellick, Yuri G. Anissimov, Michael Weiss & Michael S. Roberts
Abstract    Full Article (PDF)

Characterization of Ca2+ influx through recombinant P2X receptor in C6BU-1 cells 1484
Shinya Ueno, Shuichi Koizumi & Kazuhide Inoue
Abstract    Full Article (PDF)

Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells 1491
John M. Dickenson, Jonathan L. Blank & Stephen J. Hill
Abstract    Full Article (PDF)

Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats 1500
Kimmo Lönnrot, Ilkka Pörsti, Hannu Alho, Xiumin Wu, Antti Hervonen & Jari-Petteri Tolvanen
Abstract    Full Article (PDF)

Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226 1507
Ants Kask, Lembit Rägo & Jaanus Harro
Abstract    Full Article (PDF)

Glycodermorphins: opioid peptides with potent and prolonged analgesic activity and enhanced blood-brain barrier penetration 1516
Lucia Negri, Roberta Lattanzi, Fabio Tabacco, Barbara Scolaro & Raniero Rocchi
Abstract    Full Article (PDF)

Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands 1523
Takafumi Eguchi, Yasuko Ishikawa & Hajime Ishida
Abstract    Full Article (PDF)

Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation 1534
E.H. Cox, J.A. Kuipers & M. Danhof
Abstract    Full Article (PDF)

Activation of two types of Ca2+-permeable nonselective cation channel by endothelin-1 in A7r5 cells 1541
Yasushi Iwamuro, Soichi Miwa, Tetsuya Minowa, Taijiro Enoki, Xiao-Feng Zhang, Masatsune Ishikawa, Nobuo Hashimoto & Tomoh Masaki
Abstract    Full Article (PDF)

The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat 1550
Hans O. Kalkman, Vroni Neumann, Daniel Hoyer & Mark D. Tricklebank
Abstract    Full Article (PDF)

Diazoxide- and leptin-activated KATP currents exhibit differential sensitivity to englitazone and ciclazindol in the rat CRI-G1 insulin-secreting cell line 1557
J. Harvey & M.L.J. Ashford
Abstract    Full Article (PDF)

The inhibitory effect of nociceptin on the micturition reflex in anaesthetized rats 1566
Sandro Giuliani, Alessandro Lecci, Manuela Tramontana & Carlo Alberto Maggi
Abstract    Full Article (PDF)

Neurogenic cutaneous vasodilatation and plasma extravasation in diabetic rats: effect of insulin and nerve growth factor 1573
Gavin S. Bennett, Neil. E. Garrett, Lara T. Diemel, Susan D. Brain & David R. Tomlinson
Abstract    Full Article (PDF)

Pharmacological profile of a novel cyclic AMP-linked P2 receptor on undifferentiated HL-60 leukemia cells 1580
Arthur D. Conigrave, Joanne Y. Lee, Louise van der Weyden, Lele Jiang, Peter Ward, Vit Tasevski, Brian M. Luttrell & Michael B. Morris
Abstract    Full Article (PDF)

Erratum

1586
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