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Bone Marrow Transplantation
January 2000, Volume 25, Issue 1, Pages 109 – 110
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Title

A case of hemolytic uremic syndrome improved with nitric oxide

T Kajiume1,2, A Nagita1, S Yoshimi2, K Kobayashi1 & N Kataoka1

1Department of Pediatrics, Kawasaki Medical School, Okayama, Japan

2Satou Memorial Hospital, Okayama, Japan

Correspondence to: Dr T Kajiume, Department of Pediatrics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan


Abstract

Hemolytic uremic syndrome (HUS) after transplantation is difficult to treat, and there is no consensus regarding optimal mode of treatment. We attached transdermal isosorbide tape as a nitric oxide (NO) donor to patients with HUS after bone marrow transplantation (BMT). This was very effective in ameliorating the hemolysis and increasing platelet numbers. We report here the successful use of an isosorbide in a patient with HUS after transplantation. Bone Marrow Transplantation (2000) 25, 109–110.

Keywords
hematopoietic stem cell transplantation; hemolytic uremic syndrome; isosorbide; nitric oxide


Received 27 April 2000; Accepted 12 August 1999


© Macmillan Publishers Ltd 2000