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Gene Therapy

December 2000, Volume 7, Issue 24
Table of Contents

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Editorial

Exploring vascular heterogeneity for gene therapy targeting 2059
M Trepel, W Arap & R Pasqualini
Full Article (PDF)

Nonviral transfer technology

A novel doxycycline inducible autoregulatory plasmid which displays ‘on’/‘off’ regulation suited to gene therapy applications 2061
DJ Gould, M Berenstein, H Dreja, F Ledda, OL Podhajcer & Y Chernajovsky
Abstract    Full Article (PDF)

Acquired diseases

Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53 2071
T Komata, Y Kondo, S Koga, SC Ko, LWK Chung & S Kondo
Abstract    Full Article (PDF)

Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen 2080
W Song, Y Tong, H Carpenter, H-L Kong & RG Crystal
Abstract    Full Article (PDF)

Direct intra-cardiomuscular transfer of beta2-adrenergic receptor gene augments cardiac output in cardiomyopathic hamsters 2087
K Tomiyasu, Y Oda, M Nomura, E Satoh, S Fushiki, J Imanishi, M Kondo & O Mazda
Abstract    Full Article (PDF)

Demyelination but no cognitive, motor or behavioral deficits after adenovirus-mediated gene transfer into the brain 2094
HM Fathallah-Shaykh, AI Kafrouni, L-J Zhao, R Diaz-Arrastia, JA Garcia, WH Frawley & J Forman
Abstract    Full Article (PDF)

Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice 2099
JJ Koh, KS Ko, M Lee, S Han, JS Park & SW Kim
Abstract    Full Article (PDF)

Cell-based therapy

Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells 2105
KS Denis-Mize, M Dupuis, ML MacKichan, M Singh, B Doe, D O’Hagan, JB Ulmer, JJ Donnelly, DM McDonald & G Ott
Abstract    Full Article (PDF)

Enhancement of antitumor immunity against B16 melanoma tumor using genetically modified dendritic cells to produce cytokines 2113
Y Akiyama, M Watanabe, K Maruyama, FW Ruscetti, RH Wiltrout & K Yamaguchi
Abstract    Full Article (PDF)

Viral Transfer Technology

Virus-like gene transfer into cells mediated by polyoma virus pseudocapsids 2122
N Krauzewicz, J Stokrová, C Jenkins, M Elliott, CF Higgins & BE Griffin
Abstract    Full Article (PDF)

Adenoviral vector design for high-level transgene expression in primitive human hematopoietic progenitors 2132
X Fan, A Brun & S Karlsson
Abstract    Full Article (PDF)

Acknowledgement to Referees

2139
Full Article (PDF)

Author Index

2141
Full Article (PDF)

Keyword Index

2147
Full Article (PDF)

© Macmillan Publishers Ltd 2000

Nature Publishing Group Specialist Journals have a substantial list of leading international journals in the key areas of science and medicine. Specialist fields covered include: bone marrow transplantation, cell death and differentiation, critical care/intensive care, dentistry, dentomaxillofacial radiology, environmental epidemiology, gene therapy, hematology, human and experimental toxicology, exposure analysis, human hypertension, impotence research, industrial microbiology, industrial health, information systems, leukemia, lupus, microcirculation, molecular psychiatry, multiple sclerosis, neuroscience, nursing, nutrition, obesity, occupational medicine, oncology, oncology pharmacy practice, operations research, optometry and ophthalmology, oral diseases, orthopedics, paraplegia, perinatology, pharmacology, psychiatry, public health, spinal injury and disease.