January-February 2000, Volume 10, Issue 1, Pages 86 - 97

Article

Conceptual basis for multi-route intake dose modeling using an energy expenditure approach THOMAS MCCURDY National Exposure Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina     Correspondence to: THOMAS MCCURDY, 1915 Hillock Place, Durham, NC 27712. Tel.: (919)541-0782.     Disclaimer: The information contained in this paper has been funded in part by the U.S. Environmental Protection Agency. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

Keywords

energy expenditure;   exposure;   intake dose;   multi-route exposures

Abstract

This paper provides the conceptual basis for a modeling logic that is currently being developed in the National Exposure Research Laboratory (NERL) of the U.S. Environmental Protection Agency (EPA) for use in intake dose assessments involving substances that can enter the body via multiple routes of exposure. NERL is simultaneously developing a consolidated human activity database that will provide much of the data needed to parameterize equations used to implement the logic. EPA's Office of Air Quality Planning and Standards (OAQPS) is, in part, using the logic in its on-going review of the carbon monoxide national ambient air quality standard. Journal of Exposure Analysis and Environmental Epidemiology (2000) 10, 86-97.

Received 16 February 1998; Accepted 30 April 1999

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