Leukemia
Normal and Malignant Hemopoiesis

July 1998, Volume 12, Issue 7
Table of Contents

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Editorial

Cellular resistance mechanisms with impact on the therapy of multiple myeloma 1009
F Gieseler & V Nüßler
Abstract    Full Article (PDF)

Review

The study of apoptotic cells by flow cytometry 1013
MG Ormerod
Abstract    Full Article (PDF)

Mini-Review

Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis 1026
J Roy, C Ryckman, V Bernier, R Whittom & R Delage
Abstract    Full Article (PDF)

Original Manuscripts, Therapy And Therapeutic Interventions

Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI 1031
S Richards, J Burrett, I Hann, J Chessells, F Hill, C Bailey for the Medical Research Council Working Party on Childhood Leukemia
Abstract    Full Article (PDF)

Phase II study of carboplatin in blast crisis of chronic myeloid leukemia: Eastern Cooperative Oncology Group Study E1992 1037
JP Dutcher, S Lee, E Paietta, JM Bennett, JA Stewart & PH Wiernik
Abstract    Full Article (PDF)

Comparison between four and eight cycles of intensive chemotherapy in adult acute myeloid leukemia: a randomized trial of the Finnish Leukemia Group 1041
E Elonen, A Almqvist, A Hänninen, S-E Jansson, G Järventie, P Koistinen, E Koivunen, R Lahtinen, M Lehtinen, T Nousiainen, T-T Pelliniemi, A Rajamäki, K Remes, T Timonen, J Vilpo, L Volin & T Ruutu
Abstract    Full Article (PDF)

Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia: results of an age-adjusted prospective randomized comparison 1049
W Kern, C Aul, G Maschmeyer, R Schönrock-Nabulsi, WD Ludwig, A Bartholomäus, P Bettelheim, B Wörmann, T Büchner, W Hiddemann for the German AML Cooperative Group
Abstract    Full Article (PDF)

Clinical-Laboratory Correlates

Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia 1056
A Venditti, G Del Poeta, F Buccisano, A Tamburini, MC Cox-Froncillo, G Aronica, A Bruno, B Del Moro, AM Epiceno, A Battaglia, L Forte, M Postorino, V Cordero, S Santinelli & S Amadori
Abstract    Full Article (PDF)

Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity 1064
O Hrus caronák, J Trka, J Zuna, J Housková, J Bartu ringn caronková, J Starý for the Pediatric Hematology Working Group in the Czech Republic
Abstract    Full Article (PDF)

Classification Of Acute Myeloid Leukemias

Acute myeloblastic leukemia with minimal myeloid differentiation: phenotypical and ultrastructural characteristics 1071
N Villamor, M-A Zarco, M Rozman, J-M Ribera, E Feliu & E Montserrat
Abstract    Full Article (PDF)

Minimal Residual Disease In CML

Does BCR-ABL genomic rearrangement persist in CML patients in complete remission after interferon alpha therapy? 1076
F Brizard, JC Chomel, A Veinstein, J Rivet, C Giraud, A Kitzis, F Guilhot & A Brizard
Abstract    Full Article (PDF)

Molecular Immunology In ALL

Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease 1081
T Szczepaski, AW Langerak, ILM Wolvers-Tettero, GJ Ossenkoppele, G Verhoef, M Stul, EJ Petersen, MAC de Bruijn, MB van’t Veer & JJM van Dongen
Abstract    Full Article (PDF)

Hematopoietic Receptor Genes

Specific and common activities of the FLT3 and KIT tyrosine kinase receptors revealed by the use of cultured mast cells 1089
N Casteran, N Beslu, E Lecocq, S Gomez & P Dubreuil
Abstract    Full Article (PDF)

Molecular Cytogenetics

Abnormalities of the ETV6 gene occur in the majority of patients with aberrations of the short arm of chromosome 12: a combined PCR and Southern blotting analysis 1099
HE O’Connor, TA Butler, R Clark, S Swanton, CJ Harrison, LM Secker-Walker & L Foroni
Abstract    Full Article (PDF)

High-resolution allelotype analysis of childhood B-lineage acute lymphoblastic leukemia 1107
C Chambon-Pautas, H Cavé, B Gérard, C Guidal-Giroux, M Duval, E Vilmer & B Grandchamp
Abstract    Full Article (PDF)

Tumor Suppressor Genes, Signal Transduction And Cell Cycle

Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia 1114
R Wieser, B Gruber, H Rieder & C Fonatsch
Abstract    Full Article (PDF)

Megakaryocytopoiesis And MLL Amplification

Establishment and characterization of a megakaryoblast cell line with amplification of MLL 1119
RJ Allen, SD Smith, RL Moldwin, M-M Lu, L Giordano, C Vignon, Y Suto, A Harden, R Tomek, T Veldman, T Ried, RA Larson, MM Le Beau, JD Rowley & N Zeleznik-Le
Abstract    Full Article (PDF)

Stromal Cell Biology: A Transgenic Mouse Model

Transplantation of stromal cells transduced with the human IL3 gene to stimulate hematopoiesis in human fetal bone grafts in non-obese, diabetic-severe combined immunodeficiency mice 1128
N Brouard, A Chapel, TMA Neildez-Nguyen, C Granotier, I Khazaal, B Péault & D Thierry
Abstract    Full Article (PDF)

Matrix Metallo Proteinase

Autocrine regulation of matrix metalloproteinase-9 gene expression and secretion by tumor necrosis factor-alpha (TNF-alpha) in NB4 leukemic cells: specific involvement of TNF receptor type 1 1136
MG Ismair, C Ries, F Lottspeich, C Zang, HJ Kolb & PE Petrides
Abstract    Full Article (PDF)

Myeloma

Maintenance treatment with interferon alpha-2b in multiple myeloma: a prospective randomized study from PETHEMA (Program for the Study and Treatment of Hematological Malignancies, Spanish Society of Hematology) 1144
J Bladé, JF San Miguel, ML Escudero, M Fontanillas, J Besalduch, S Gardella, J Arias, J García-Conde, M Carnero, JM Marti, C Rozman, J Estapé & E Montserrat
Abstract    Full Article (PDF)

In vitro excess ammonia production in human myeloma cell lines 1149
T Otsuki, O Yamada, H Sakaguchi, T Ichiki, K Kouguchi, H Wada, H Hata, Y Yawata & A Ueki
Abstract    Full Article (PDF)

Brief Communication

Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH 1159
M-A Dragon-Durey, A-F Goguel, C Leonard, R Berger, B Bressac-de-Paillerets, D Fauvet & A Bernheim
Abstract    Full Article (PDF)

Correspondence

BCL6 rearrangement and mediastinal involvement in a case of B cell acute lymphoblastic leukemia 1163
JE Rubnitz, B Abushullaih, SC Kaste, SC Raimondi, JT Sandlund, C-H Pui & FG Behm
Full Article (PDF)

Chronic myeloid leukemia with e19a2 (c3a2) BCR/ABL fusion junction - is it truly a benign disease? 1166
GF How, LT Tan & LC Lim
Full Article (PDF)

ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders 1167
T Nilsson, P Andreasson, M Höglund, T Fioretos, R Billström, S Garwicz, F Mitelman & B Johansson
Full Article (PDF)

Comments On Published Papers

SFT Thijsen et al. Hypersensitivity of bcr-abl progenitors to hyperthermia in patients with chronic myeloid leukemia 1168
M Baccarani
Full Article (PDF)

Response to Michele Baccarani 1169
SFT Thijsen, GJ Schuurhuis, JW van Oostveen & GJ Ossenkoppele
Full Article (PDF)


© Macmillan Publishers Ltd 1998

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