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Original Articles
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Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response
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1
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Eija I Korpelainen, Marika Kärkkäinen, Yuji Gunji, Miikka Vikkula & Kari Alitalo
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The adenovirus E4orf6 protein contributes to malignant transformation by antagonizing E1A-induced accumulation of the tumor suppressor protein p53
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9
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Michael Nevels, Thilo Spruss, Hans Wolf & Thomas Dobner
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Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation
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19
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Jörk Zwicker, Sabine Brüsselbach, Karin U Jooss, Andreas Sewing, Moira Behn, Frances C Lucibello & Rolf Müller
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| Abstract Full Article PDF
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Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors
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27
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Marilyn Khanna, Pat Park, Monib Zirvi, Weiguo Cao, Antonio Picon, Joseph Day, Philip Paty & Francis Barany
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| Abstract Full Article PDF
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Human ubiquitous JCV(CY) T-antigen gene induces brain tumors in experimental animals
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39
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Barbara Krynska, Jessica Otte, Roberta Franks, Kamel Khalili & Sidney Croul
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A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival
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47
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Jonathan P. Moorman, Dien Luu, Jeffrey Wickham, David A Bobak & Chang S Hahn
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Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium
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59
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Timothy D Jenkins, Annegret Mueller, Robert Odze, Aliakbar Shahsafaei, Lawrence R Zukerberg, Ralph Kent, Gary D Stoner & Anil K Rustgi
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Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility
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67
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Ravi Salgia, Jian-Liang Li, Darren S Ewaniuk, You-Bin Wang, Martin Sattler, Wen-Che Chen, William Richards, Evan Pisick, Geoffrey I Shapiro, Barrett J Rollins, Lan Bo Chen, James D Griffin & David J Sugarbaker
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Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia
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79
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Uwe R Peters, Urs Hasse, Elisabeth Oppliger, Mario Tschan, S Tiong Ong, Feyruz V Rassool, Bettina Borisch, Andreas Tobler & Martin F Fey
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Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras
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87
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Olivier Lorentz, Axelle Cadoret, Isabelle Duluc, Jacqueline Capeau, Christian Gespach, Gisèle Cherqui & Jean-Noël Freund
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Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells
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93
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Yong Xu, Anuradha Krishnan, X Steven Wan, Hideyuki Majima, Che-Chung Yeh, Gabriele Ludewig, Edward J Kasarskis & Daret K St.Clair
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Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells
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103
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Hirofumi Yamamoto, Jae-Won Soh, Haim Shirin, Wang-Qiu Xing, Jin TE Lim, Yao Yao, Eric Slosberg, Naohiro Tomita, Ira Schieren & I Bernard Weinstein
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The polyadenylation inhibitor cordycepin (3'dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels
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117
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Panayotis Ioannidis, Nelly Courtis, Maria Havredaki, Emmanuel Michailakis, Chris M Tsiapalis & Theoni Trangas
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PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
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127
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Susana Velasco-Miguel, Leonard Buckbinder, Patrice Jean, Larry Gelbert, Randy Talbott, Jana Laidlaw, Bernd Seizinger & Nikolai Kley
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Retinoic acid inhibits transformation by preventing phosphatidylinositol 3-kinase dependent activation of the c-fos promoter
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139
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Yachi Chen, Robert Freund, Mark Listerud, Zuohong Wang & David A Talmage
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Chimeric Wnt proteins define the amino-terminus of Wnt-1 as a transformation-specific determinant
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149
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Martin A Julius, Seema D Rai & Jan Kitajewski
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Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31
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157
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Maryse Simoneau, Tahar O Aboulkassim, Hélène LaRue, François Rousseau & Yves Fradet
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Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation
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165
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Satoshi Iwata, Yuya Sato, Minoru Asada, Masatoshi Takagi, Atsumi Tsujimoto, Toshiya Inaba, Takayuki Yamada, Shunji Sakamoto, Jun-ichi Yata, Tomomi Shimogori, Kazuei Igarashi & Shuki Mizutani
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ASK1 mediates apoptotic cell death induced by genotoxic stress
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173
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Zhihong Chen, Hiroyuki Seimiya, Mikihiko Naito, Tetsuo Mashima, Atsuo Kizaki, Shingo Dan, Miki Imaizumi, Hidenori Ichijo, Kohei Miyazono & Takashi Tsuruo
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Microsatellite instability in European hepatocellular carcinoma
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181
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Marina Salvucci,, Antoinette Lemoine, Raphaël Saffroy, Daniel Azoulay, Bénédicte Lepère, Stéphanie Gaillard, Henri Bismuth, Michel Reynès & Brigitte Debuire
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Comparative study of the p53-mdm2 and p53-MDMX interfaces
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189
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Volker Böttger, Angelika Böttger, Carlos Garcia-Echeverria, Yolande FM Ramos, Alex J van der Eb, Aart G Jochemsen & David P Lane
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Resistance to avian leukosis virus lymphomagenesis occurs subsequent to proviral c-myc integration
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201
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Kelly J Bird, Helen L Semus & Alanna Ruddell
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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features
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211
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D Roland Walker, Jeffrey P Bond, Robert E Tarone, Curtis C Harris, Wojciech Makalowski, Mark S Boguski & Marc S Greenblatt
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Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis
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219
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FJ Fogerty, J-L Juang, J Petersen, MJ Clark, FM Hoffmann & DF Mosher
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Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma
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233
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K Wimmer, XX Zhu, BJ Lamb, R Kuick, PF Ambros, H Kovar, D Thoraval, S Motyka, JR Alberts & SM Hanash
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Cyclin D1 Associates with the TBP-associated factor TAFII250 to regulate Sp1-mediated transcription
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239
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Jalila Adnane, Zhaohui Shao & Paul D Robbins
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Short Reports
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Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells
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249
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Philip Chen, Magtouf Gatei, Matthew J O'Connell, Kum Kum Khanna, Sarah J Bugg, Annette Hogg, Shaun P Scott, Karen Hobson & Martin F Lavin
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Differential expression of NF1 type I and type II isoforms in sporadic borderline and invasive epithelial ovarian tumors
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257
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Tara D Iyengar, Shu-wing Ng, Ching C Lau, William R Welch, Debra A Bell, Ross S Berkowitz & Samuel C Mok
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The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
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263
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YuLi Chai, Jian-qi Cui, Ningsheng Shao, E Shyam P Reddy & Veena N Rao
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Functional association of TGF- receptor II with cyclin B
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269
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Jin Hong Liu, Sheng Wei, Pearlie K Burnette, Ana M Gamero, Michael Hutton & Julie Y Djeu
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p16INK4 mediates contact-inhibition of growth
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277
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Raimund J Wieser, Dagmar Faust, Cornelia Dietrich & Franz Oesch
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