Tumor Targeting

April 1999, Volume 4, Issue 1, Pages 3 - 11

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Review
Vector development for cancer gene therapy

K-W Peng & R Vile

Molecular Medicine Program, Guggenheim 18, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA    

Correspondence to: Dr R Vile , Molecular Medicine Program, Guggenheim 18, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA    

Keywords
viral vectors;   gene therapy;   targeting;   titre

Abstract

With results now coming through from the first trials of gene therapy in tumor patients, it is clear that improvements need to be made to the efficiency of gene delivery vectors. Improvements in vector titre go hand in hand with developments in vector targeting. As well as refining existing vector systems, there is a place now for imaginative thinking to create novel vectors which cross, and extend, established concepts of vector design. These novel vectors will come from combining the beneficial features of different individual systems and looking towards new and untried vectors still waiting to be exploited.

© Macmillan Publishers Ltd 1999