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British Journal of Pharmacology

October 1998, Volume 125, Issue 4
Table of Contents

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Special Reports

Endothelium-dependent and -independent responses to protease-activated receptor-2 (PAR-2) activation in mouse isolated renal arteries 591
J.D. Moffatt & T.M. Cocks
Abstract    Full Article (PDF)

The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor 595
Olivier Blondel, Monique Gastineau, Michel Langlois & Rodolphe Fischmeister
Abstract    Full Article (PDF)

Original Articles

Inhibition of serum and transforming growth factor beta (TGF-beta1)-induced DNA synthesis in confluent airway smooth muscle by heparin 599
K.B. Okona-Mensah, E. Shittu, C. Page, J. Costello & S.A. Kilfeather
Abstract    Full Article (PDF)

Metabolism of the vitamin D3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity 607
Marcus Quack, Christina Mørk Hansen, Ernst Binderup, Anne-Marie Kissmeyer & Carsten Carlberg
Abstract    Full Article (PDF)

Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy 615
A. Cleton, R.A. Voskuyl & M. Danhof
Abstract    Full Article (PDF)

NK-3 receptors mediate enhancement of substance P release from capsaicin-sensitive spinal cord afferent terminals 621
Giovanna Schmid, Francesca Carità, Giambattista Bonanno & Maurizio Raiteri
Abstract    Full Article (PDF)

Uncoupling of bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization by phorbol ester in canine cultured tracheal epithelial cells 627
Chuen-Mao Yang, Shue-Fen Luo, Wen-Bin Wu, Shiow-Lin Pan, Yih-Jeng Tsai, Chi-Tso Chiu & Chuan-Chwan Wang
Abstract    Full Article (PDF)

Vascular smooth muscle cell hypertrophy induced by glycosylated human oxyhaemoglobin 637
Concepción Peiró, Javier Angulo, Leocadio Rodríguez-Mañas, José L. Llergo, Susana Vallejo, Elena Cercas & Carlos F. Sánchez-Ferrer
Abstract    Full Article (PDF)

Infarct size-reducing effect of heat stress and alpha1 adrenoceptors in rats 645
Marie Joyeux, Diane Godin-Ribuot, Asha Patel, Pierre Demenge, Derek M. Yellon & Christophe Ribuot
Abstract    Full Article (PDF)

Haemodynamic effects of a selective adenosine A2A receptor agonist, CGS 21680, in chronic heart failure in anaesthetized rats 651
Ali A. Nekooeian & Reza Tabrizchi
Abstract    Full Article (PDF)

Mechanism of block by tedisamil of transient outward current in human ventricular subepicardial myocytes 659
Erich Wettwer, Herbert M. Himmel, Gregory J. Amos, Qi Li, Franz Metzger & Ursula Ravens
Abstract    Full Article (PDF)

Inhibitors of spasmogen-induced Ca2+ channel suppression in smooth muscle cells from small intestine 667
T. Unno, D.J. Beech, S. Komori & H. Ohashi
Abstract    Full Article (PDF)

Analysis of the influence of nucleotidases on the apparent activity of exogenous ATP and ADP at P2Y1 receptors 675
Paul Vigne, Jean Philippe Breittmayer & Christian Frelin
Abstract    Full Article (PDF)

Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats 681
Saadia Eddahibi, Bernadette Raffestin, Anne-Charlotte Le Monnier de Gouville & Serge Adnot
Abstract    Full Article (PDF)

The actions of the cannabinoid receptor antagonist, SR 141716A, in the rat isolated mesenteric artery 689
Richard White & C. Robin Hiley
Abstract    Full Article (PDF)

Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited beta-adrenergic mucin secretion response 697
M.M.C. Pereira, C. Lloyd Mills, R.L. Dormer & M.A. McPherson
Abstract    Full Article (PDF)

Contributions of cysteine 114 of the human D3 dopamine receptor to ligand binding and sensitivity to external oxidizing agents 705
Glen L. Alberts, Jeffrey F. Pregenzer & Wha Bin Im
Abstract    Full Article (PDF)

Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways 711
H.-P. Kuo, K.-H. Hwang, H.-C. Lin, C.-H. Wang, C.-Y. Liu & L.-C. Lu
Abstract    Full Article (PDF)

Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor 717
J. McDonnell, M.L. Latif, E.S. Rees, N.J. Bevan & S.J. Hill
Abstract    Full Article (PDF)

Comparative desensitization of the human 5-HT2A and 5-HT2C receptors expressed in the human neuroblastoma cell line SH-SY5Y 727
S.J. Briddon, R.A. Leslie & J.M. Elliott
Abstract    Full Article (PDF)

Contrasting effects of an aminobisphosphonate, a potent inhibitor of bone resorption, on lipopolysaccharide-induced production of interleukin-1 and tumour necrosis factor alpha in mice 735
Shunji Sugawara, Masahiko Shibazaki, Haruhiko Takada, Hiroshi Kosugi & Yasuo Endo
Abstract    Full Article (PDF)

Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors 741
A. Raes, G. Van de Vijver, M. Goethals & P.P. van Bogaert
Abstract    Full Article (PDF)

Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy 751
S. Bertrand, S. Weiland, S.F. Berkovic, O.K. Steinlein & D. Bertrand
Abstract    Full Article (PDF)

Activation of the cloned human NK3 receptor in Chinese Hamster Ovary cells characterized by the cellular acidification response using the Cytosensor microphysiometer 761
R.E. Jordan, D. Smart, P. Grimson, N. Suman-Chauhan & A.T. McKnight
Abstract    Full Article (PDF)

The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment 767
L. Pickavance, P.S. Widdowson, P. King, S. Ishii, H. Tanaka & G. Williams
Abstract    Full Article (PDF)

Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons 771
Yu Zhong, Philip M. Dunn, Zhenghua Xiang, Xuenong Bo & Geoffrey Burnstock
Abstract    Full Article (PDF)

Recovery by ascorbate of impaired nitric oxide-dependent relaxation resulting from oxidant stress in rat aorta 782
Sinead Dudgeon, David P. Benson, Andrew MacKenzie, Karen Paisley-Zyszkiewicz & William Martin
Abstract    Full Article (PDF)

Desensitization of ETA endothelin receptor-mediated negative chronotropic response in right atria - species difference and intracellular mechanisms 787
Kageyoshi Ono, Aiji Sakamoto, Tomoh Masaki & Motoyoshi Satake
Abstract    Full Article (PDF)

Effects of intracerebroventricular leptin administration on food intake, body weight gain and diencephalic nitric oxide synthase activity in the mouse 798
Gioacchino Calapai, Francesco Corica, Alessandro Allegra, Andrea Corsonello, Lidia Sautebin, Tiziana De Gregorio, Massimo Di Rosa, Giuseppina Costantino, Michele Buemi & Achille P. Caputi
Abstract    Full Article (PDF)

Discovery of novel selective hypotensive vasopressin peptides that exhibit little or no functional interactions with known oxytocin/vasopressin receptors 803
W.Y. Chan, N.C. Wo, S. Stoev, L.L. Cheng & M. Manning
Abstract    Full Article (PDF)

Heat stress-induced B1 receptor synthesis in the rat: an ex vivo study 812
Caroline Lagneux, Patricia Innocenti-Francillard, Diane Godin-Ribuot, Mickael Bader & Christophe Ribuot
Abstract    Full Article (PDF)

Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: Effects of the superoxide anion radical scavenger, tempol, on organ injury 817
Mary Leach, Stefan Frank, Antje Olbrich, Josef Pfeilschifter & Christoph Thiemermann
Abstract    Full Article (PDF)

Frequency-dependent inhibition of neuronal activity by topiramate in rat hippocampal slices 826
Shang-Peng Wu, Jing-Jane Tsai & Po-Wu Gean
Abstract    Full Article (PDF)

Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors 833
K.S.M. Smalley, W. Feniuk & P.P.A. Humphrey
Abstract    Full Article (PDF)

Induction by interleukin-1, tumor necrosis factor and lipopolysaccharides of histidine decarboxylase in the stomach and prolonged accumulation of gastric acid 842
Yasuo Endo & Katsuo Kumagai
Abstract    Full Article (PDF)

Pharmacological characterization of endothelin-induced contraction in the guinea-pig oesophageal muscularis mucosae 849
Kohsuke Uchida, Rika Yuzuki & Yuichiro Kamikawa
Abstract    Full Article (PDF)

Effects of mexiletine on ATP sensitive K+ channel of rat skeletal muscle fibres: a state dependent mechanism of action 858
Domenico Tricarico, Mariagrazia Barbieri, Carlo Franchini, Vincenzo Tortorella & Diana Conte Camerino
Abstract    Full Article (PDF)

Characterization of receptors mediating contraction of the rat isolated small mesenteric artery and aorta to arginine vasopressin and oxytocin 865
Wiro B. Stam, Pieter H. Van der Graaf & Pramod R. Saxena
Abstract    Full Article (PDF)

Effects of sulphonylureas on the volume-sensitive anion channel in rat pancreatic beta-cells 874
L. Best & S. Benington
Abstract    Full Article (PDF)

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population 879
Catherine Spire-Vayron de la Moureyre, Hervé Debuysere, Bruno Mastain, Elizabeth Vinner, Delphine Marez, Jean-Marc Lo Guidice, Dany Chevalier, Serge Brique, Kokou Motte, Jean-Frédéric Colombel, Dominique Turck, Christian Noel, René-Marc Flipo, Annie Pol, Michel Lhermitte, Jean-Jacques Lafitte, Christian Libersa & Franck Broly
Abstract    Full Article (PDF)

Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures 888
Enzo Nisoli, Emilio Clementi, Cristina Tonello, Clara Sciorati, Luca Briscini & Michele O. Carruba
Abstract    Full Article (PDF)

Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo 895
David W. Laight, K.M. Kengatharan, Nitin K. Gopaul, Erik E. Änggård & Martin J. Carrier
Abstract    Full Article (PDF)

A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs 902
Masaki Fujimura, Tokunao Amemiya, Shigeharu Myou, Yoshihisa Ishiura, Shigeki Sasaki & Tamotsu Matsuda
Abstract    Full Article (PDF)

Effects of prenatal exposure to low concentrations of carbon monoxide on sexual behaviour and mesolimbic dopaminergic function in rat offspring 909
Raffaele Cagiano, Donata Ancona, Tommaso Cassano, Maria Tattoli, Luigia Trabace & Vincenzo Cuomo
Abstract    Full Article (PDF)

Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors 916
János Szolcsányi, Erika Pintér, Zsuzsanna Helyes, Gábor Oroszi & József Németh
Abstract    Full Article (PDF)

© Macmillan Publishers Ltd 1998

As part of one of the world's largest publishers, Stockton Press has a substantial list of leading international journals in the key areas of science and medicine. Specialist fields covered include: bone marrow transplantation, cell death and differentiation, critical care/intensive care, dentistry, dentomaxillofacial radiology, environmental epidemiology, gene therapy, hematology, human and experimental toxicology, exposure analysis, human hypertension, impotence research, industrial microbiology, industrial health, information systems, leukemia, lupus, microcirculation, molecular psychiatry, multiple sclerosis, neuroscience, nursing, nutrition, obesity, occupational medicine, oncology, oncology pharmacy practice, operations research, optometry and ophthalmology, oral diseases, orthopedics, paraplegia, perinatology, pharmacology, psychiatry, public health, spinal injury and disease.